The lithium, sodium, boron and aluminum end up as soluble inorganic salts at the end of either reaction. The fourth valence electron of carbon remains in its porbital and forms a. Background to the reactions the reducing agents despite the fearsome names. Sodium borohydride can be used safely and effectively in water as well as alcohol solvents, whereas special precautions are required when using lithium aluminium hydride.
Reduction of the ozonide compound with the help of zinc dust and water produces the smaller molecules, which in this case will be the respective aldehydes and ketones. A simple and rapid procedure for the almost quantitative reduction of aromatic aldehydes, ketones, diketones and oxo aldehydes to alcohols by use of ticl3nh3 in aqueous methanol solution is reported. Sch 206 reactions of ketones and aldehydes nucleophilic. The key step in the reduction of a carbonyl compound by either lithium aluminum hydride or. Reactions of alcohols, phenols, aldehydes and ketones free download as powerpoint presentation. Given the structure of an alcohol, ether, thiol, sulfide, aldehyde, or ketone molecule, be able to give the systemic names and vice versa.
As the nucleophile attacks the carbonyl group, the carbon atom changes from sp2 to sp3. The reaction produces aldehydes, ketones and in some cases both the compounds on the basis of the substitution arrangement of the alkene compounds. This is usually the addition of a nucleophile and a proton across the co double bond. As these examples illustrate, reduction of an aldehyde gives a primary alcohol, and reduction of a ketone gives a secondary alcohol. Explosion hazards of mixtures of reductants and oxidants used in r eprocessing snf dtstart. Reduction of aldehydes and ketones this page looks at the reduction of aldehydes and ketones by two similar reducing agents lithium tetrahydridoaluminateiii also known as lithium aluminium hydride and sodium tetrahydridoborate iii sodium borohydride. These reactions result in the net addition of the elements of h 2 across the cao bond. Origin of the genetic code and abiotic synthesis of. A class of pyrazole derivatives is described for use in treating p38 kinase mediated disorders. Compounds of particular interest are defined by formula ia, wherein r. Scribd is the worlds largest social reading and publishing site. Alcohols, ethers, aldehydes, and ketones educational goals 1.
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